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The most important difference is the order in which the elements are connected together, the functional groups as we say in chemistry. C,H and O can be arranged (in differing numbers) to make alcohols, aldehydes, ketones, acids and esters, to name just the obvious ones. When it comes to macromolecules you can get carbohydrates and fats for instance. The number of atoms also matters, so you can get many different examples within each class.

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