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] Description: Methacrylate-based coating materials with a variety of functional properties.

Functionality Trade name Anionic polymer of methacrylic acid and methacrylates with a -COOH group Eudragit® L 100-55 - powder, spray dried L 30 D-55 which can be reconstituted for targeted delivery in the duodenum

Eudragit® L 30 D-55 - aqueous dispersion, pH dependent polymer soluble above pH 5.5 for targeted delivery in the duodenum

Eudragit® L 100 - powder, pH dependent polymer soluble above pH 6.0 for targeted delivery in the jejunum

Eudragit® S 100 - powder, pH dependent polymer soluble above pH 7.0 for targeted delivery in the ileum.

Eudragit® FS 30 D - aqueous dispersion, pH dependent polymer soluble above pH 7.0, requires no plasticizer

Cationic polymer with a dimethylaminoethyl ammonium group Eudragit E 100 - granules, pH dependent, soluble in gastric fluid up to 5.0, swellable and permeable above pH 5.0.

Eudragit® E PO - powder form of E-100

Copolymers of acrylate and methacrylates with quarternary ammonium group. Insoluble, High Permeability

Eudragit® RL 30D - aqueous dispersion, pH independent polymer for sustained release formulations

Eudragit® RL PO - powder, pH independent polymer for matrix formulations

Eudragit® RL 100 - granules, pH independent

Insoluble, Low Permeability

Eudragit® RS 30D - aqueous dispersion, pH independent polymer for sustained release formulations

Eudragit® RS PO - powder, pH independent polymer for matrix formulations

Eudragit® RS 100 - granules, pH independent

Copolymers of acrylate and methacrylates with quarternary ammonium group in combination with sodium carboxymethylcellulose Eudragit RD 100 - powder, pH independent for fast disintegrating films

2) Applications:

Enteric Coatings Eudragit® L 100-55 or L 30 D-55 - delivery to the duodenum (pH > 5.0). Exact pH controlled drug release can be adjusted by a combination of polymers and coating thickness.

Eudragit® L 100 - delivery to the jejunum (pH > 6.0).

Eudragit® S 100 - delivery to the intestine (pH 6.0 to 7.5), site specific drug delivery can be achieved by combining with Eudragit® L types.

Eudragit® FS 30 D - delivery to the colon (pH >7.0).

Acryl-eze® --one step dry enteric coating system, soluble at pH 5.5

Sustained Release Coatings Eudragit® RL and RS - release profile determined by the ratio of RL to RS polymers, and the film thickness applied. Taste Masking Eudragit® RD 100, pH independent, fast disintegrating film

Eudragit® E 100 and EPO, pH dependent cationic polymer, soluble in gastric fluid up to pH 5.0, swellable and permeable above pH 5.0

Rapidly disintegrating Films Eudragit® RD 100
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What is the difference between eudragit RS PO and eudragit RL PO?

Solid substances obtained from EUDRAGIT® RL 100 or EUDRAGIT® RS 100. EUDRAGIT® RL PO (Type A) and EUDRAGIT® RS PO (Type B) are described in the monographs quoted above. EUDRAGIT® RL 100 / RL PO and EUDRAGIT® RS 100 / RS PO are copolymers of ethyl acrylate, methyl methacrylate and a low content of a methacrylic acid ester with quaternary ammonium groups (trimethylammonioethyl methacrylate chloride). The ammonium groups are present as salts and make the polymers permeable. The molar ratio of ethyl acrylate, methyl methacrylate and trimethylammonioethyl methacrylate is approx. 1:2:0.2 in EUDRAGIT RL and approx. 1:2:0.1 in EUDRAGIT RS.


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