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Some examples of infectious prion diseases include scrapie in sheep and goats, kuru in cannibalistic humans of Papua New Guinea, and BSE, or mad cow disease, which is transmitted to humans through infected beef products.
Alzheimer's Disease is a transmissible prion/protein disease.
Researchers injected mice with brain matter from an AD victim and the mouse developed brain lesions.(Jucker, Walker, 2010)
betaamyloidcjd.blogspot.com/2010/08/transcellular-spread-of-cytosolic.html
David Colby & Stanley Prusiner - Released January 2011 ENLARGING SPECTRUM OF PRION-LIKE DISEASES
cshperspectives.cshlp.org/content/3/1/a006833.full.pdf+html
"The discovery that prions form amyloid prompted one of us to suggest that the common neurodegenerative diseases are also caused by prions (Prusiner 1984; Prusiner 2001) despite the inability to transmit such illnesses to monkeys and apes (Goudsmit et al. 1980).
"Taken together, these findings argue that prion-like, self-propagating states feature in many different, if not all, neurodegenerative diseases."
Regarding transmission to monkeys and apes, in 2007 in the UK, researchers injected marmosets with AD brain homogenates, and some of the animals developed AD-like amyloid plaques (Baker, Ridley, et al 2007) kxnet.com/getForumPost.asp?setCity=bis&ArticleId=113652
Alzheimer's is a prion disease: sludgevictims.com/pathogens/ALZHEIMERS_is_a_prion_disease.pdf
Recently Nobel Laureate Stanley Prusiner and Dr. Warren Olanow said Parkinson's Disease (PD - 1 million victims) is also most likely a prion disease:
"It is thus possible that PD is a prion disorder resulting from increased production and/or impaired clearance of
proteins such as a-synuclein, leading to misfolding and the formation of toxicoligomers, aggregates, and cell death.
Further, it is possible that a-synuclein is a prion protein that can self-aggregate and be transmitted to unaffected cells, thus extending the disease process.'
pnas.org/content/106/31/12571.full
What else can I help you with?
How serious is prion disease?
All prion diseases are inevitably fatal; there are no known cures.
How do people get sporadic prion disease?
Sporadic prion diseases occur spontaneously without a known cause. It is believed to be caused by the misfolding of normal cellular prion proteins into infectious, disease-causing forms. The risk factors for sporadic prion diseases are not well understood, and there is currently no definitive way to prevent or predict their occurrence.
How are Prion diseases acquired?
Prion diseases are acquired through exposure to abnormal prion proteins that can enter the body through consumption of contaminated food, surgical procedures using contaminated instruments, or inheritance of mutated genes. Once inside the body, these abnormal prion proteins convert normal proteins into infectious forms, leading to disease.
Is there a cure for Prion disease?
Currently, there is no known cure for prion diseases. Treatment mainly focuses on managing symptoms and providing comfort care to improve the quality of life for patients. Research is ongoing to develop potential treatments for prion diseases, but no definitive cure exists at this time.
What organic molecule is a prion?
A prion is a misfolded form of a protein molecule, specifically the prion protein (PrP). It can induce other normally folded PrP proteins to adopt the misfolded conformation, leading to the spread of prion diseases.
Is a prion a virus?
No, although there is a hypothesis that prion diseases are associated with an undetected viral pathogen.
How serious is prion disease?
All prion diseases are inevitably fatal; there are no known cures.
Is a prion a protein?
Yes, a prion is a type of protein that can cause infectious diseases in animals and humans.
How do people get sporadic prion disease?
Sporadic prion diseases occur spontaneously without a known cause. It is believed to be caused by the misfolding of normal cellular prion proteins into infectious, disease-causing forms. The risk factors for sporadic prion diseases are not well understood, and there is currently no definitive way to prevent or predict their occurrence.
What is a well known prion disease?
There are multiple prion diseases, including bovine spongiform encephalopathy (BSE), or "mad cow disease."
How are Prion diseases acquired?
Prion diseases are acquired through exposure to abnormal prion proteins that can enter the body through consumption of contaminated food, surgical procedures using contaminated instruments, or inheritance of mutated genes. Once inside the body, these abnormal prion proteins convert normal proteins into infectious forms, leading to disease.
Is there a cure for Prion disease?
Currently, there is no known cure for prion diseases. Treatment mainly focuses on managing symptoms and providing comfort care to improve the quality of life for patients. Research is ongoing to develop potential treatments for prion diseases, but no definitive cure exists at this time.
What organic molecule is a prion?
A prion is a misfolded form of a protein molecule, specifically the prion protein (PrP). It can induce other normally folded PrP proteins to adopt the misfolded conformation, leading to the spread of prion diseases.
What type of research is being done on prion disease?
Research on prion diseases such as Creutzfeldt-Jakob disease and mad cow disease focuses on understanding the mechanisms of prion protein misfolding and aggregation, developing diagnostic tools, identifying potential therapeutic targets, and exploring strategies for prevention and treatment. Studies also investigate the transmission of prion diseases between species and the potential risks related to food safety and public health.
How many human diseases are caused by prions?
Human Prion DiseasesCreutzfeldt-Jakob Disease (CJD) Variant Creutzfeldt-Jakob Disease (vCJD)Gerstmann-Straussler-Scheinker SyndromeFatal Familial InsomniaKuru
What is the treatment for prion disease?
There is no specific treatment for prion diseases such as Creutzfeldt-Jakob disease. Treatment focuses on managing symptoms, providing supportive care, and making the patient as comfortable as possible. Research is ongoing to develop potential treatments.
Can prions affect a prion?
Yes, prions can interact with and convert other normal proteins into misfolded prion proteins, propagating the disease process. This conversion leads to the accumulation of abnormal prions in the brain, causing neurodegenerative diseases such as Creutzfeldt-Jakob disease.
