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The literal definition of the term macromolecule implies any large molecule. The term macromolecule was coined by Nobel laureate Hermann Staudinger in the 1920s.
In the context of science and engineering, the term may be applied to conventional polymers and biopolymers (such as DNA) as well as non-polymeric molecules with large molecular mass such as lipids or macrocycles. However, other large networks of atoms, such as metallic covalent networks or fullerenes, are not generally described as macromolecules.

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