Answer is Vitamin D.(1,25 bihydroxycholecalciferol. )
Too much calcium makes the bones brittle.
Calcium is important for healthy bone and tooth. But excessive presence of calcium in blood may cause some problems, such as tiredness, loss of appetite, vomiting.etc. It may also cause diarrhea leading to dehydration and thirst. Sometime with high calcium in blood may cause confusion and a person may become unconscious. High calcium level in blood may indicate excessive secretion of parathyroid hormone which should be treated. High calcium in blood also indicate bone disease. Excessive drinking of milk and frequent intake of antacids can increase calcium level in blood.
The parathyroid glands play a crucial role in regulating calcium ion levels in the blood. They secrete parathyroid hormone (PTH), which increases blood calcium levels by promoting the release of calcium from bones, reabsorption in the kidneys, and absorption from the intestines. Additionally, the thyroid gland influences calcium regulation through the secretion of calcitonin, which lowers blood calcium levels by inhibiting bone resorption. Together, these glands maintain calcium homeostasis essential for bone health.
Parathyroid hormone (PTH) is more important in maintaining blood calcium levels than in maintaining bone strength. When blood calcium levels drop, PTH is released from the parathyroid glands, stimulating the release of calcium from bones, reabsorption in the kidneys, and activation of vitamin D, which increases intestinal absorption of calcium. This prioritization of calcium homeostasis over bone strength can lead to bone density loss if PTH levels are chronically elevated.
Parathyroid hormone helps regulate calcium levels in the body by increasing the amount of calcium in the blood. It does this by stimulating the release of calcium from bones, increasing the absorption of calcium from the intestines, and reducing the excretion of calcium by the kidneys.
calcitonin and PTH
Too much calcium makes the bones brittle.
Calcification means calcium is being deposited somewhere. Vascular calcification means there are deposits of calcium in the blood vessels. This turns the vessels hard like bone.
The strength and rigidity of the bone is a result of the inorganic salts deposited in the matrix. Matrix is basically just large amount of non-cellular materials, which is what your bones are made of.
Bone cells take calcium and phosphorus from the blood to keep the bone hard and strong. These minerals are essential for bone mineralization and strength.
The hormone that helps remove calcium from the blood and store it in bone is calcitonin. It works by inhibiting the activity of osteoclasts, the cells responsible for breaking down bone tissue and releasing calcium into the blood. By promoting bone mineralization, calcitonin helps regulate calcium levels in the blood.
Osteoclasts
Bone cells that liquefy the bone matrix and release calcium into the blood are called Osteoclasts. Immature or matrix depositing bone cells are called osteoblasts.
Osteoclasts are cells responsible for breaking down bone tissue to release calcium into the bloodstream to maintain blood calcium levels.
Osteoclast
Calcium is important for healthy bone and tooth. But excessive presence of calcium in blood may cause some problems, such as tiredness, loss of appetite, vomiting.etc. It may also cause diarrhea leading to dehydration and thirst. Sometime with high calcium in blood may cause confusion and a person may become unconscious. High calcium level in blood may indicate excessive secretion of parathyroid hormone which should be treated. High calcium in blood also indicate bone disease. Excessive drinking of milk and frequent intake of antacids can increase calcium level in blood.
Bone cells take calcium from the blood in order to keep bones hard and strong. Calcium is a key mineral necessary for bone formation and maintenance.