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Chromosome puffs are regions of DNA that become structurally altered to allow for increased transcriptional activity. They close primarily due to the reestablishment of chromatin structure, which can occur through various mechanisms, including the action of histone-modifying enzymes and the binding of repressive factors that promote the condensation of chromatin. This process effectively reduces the accessibility of the DNA for transcription, leading to a decrease in gene expression in those regions. Environmental signals and developmental cues can also influence the timing and extent of puff closure.

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1w ago

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