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Changes to DNA that result in an incorrect shape, such as mutations, can lead to structural abnormalities in the DNA helix, affecting its stability and function. These alterations may disrupt the proper binding of proteins and enzymes necessary for replication and transcription, ultimately leading to errors in gene expression. Such disruptions can result in various diseases, including cancer, by promoting uncontrolled cell growth or impairing cellular functions. Additionally, incorrect DNA shapes may hinder DNA repair mechanisms, compounding the effects of the initial mutation.

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3mo ago

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