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What is the importance of acetylcholinesterase in muscle cell contraction?
If the action of acetylcholinesterase wereinhibited, the level of acetylcholine would increase as well as the duration of its action. The effect would cause muscle spasms.This is because an electrical signal, or nerve impulse, is conducted byacetylcholine across the junction between the nerve and the muscle (the synapse) stimulating the muscle to move. Normally, after the appropriate response is accomplished, acetylcholinesterase is released which breaks down the acetylcholine terminating the stimulation of the muscle. The enzyme acetylcholine accomplishes this by chemically breaking the compound into other compounds and removing them from the nerve junction.If acetylcholinesterase is unable to breakdown or remove acetylcholine, the muscle can continue to move uncontrollably.Electrical impulses can fire away continuously unless the number of messages being sent through the synapse is limited by the action of acetylcholinesterase.Repeated and unchecked firing of electrical signals can cause uncontrolled, rapid twitching of some muscles, paralyzed breathing, convulsions, and in extreme cases, death.
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