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In some types of colon cancer stem cells have a mutation in the APC gene. What happens if the APC gene is mutated?
When the APC gene is mutated, it disrupts the normal regulation of cell growth and division in the colon. APC normally acts as a tumor suppressor, helping to control the Wnt signaling pathway, which is crucial for maintaining proper cell function. A mutation can lead to uncontrolled cell proliferation, contributing to the development of benign polyps and, ultimately, colorectal cancer. This mutation is a key early event in the progression of certain types of colon cancer.
How can mutation in gene lead to a new trait in an organism?
The mutated gene codes for a protein that cause a new trait
What is muteins?
protein that is a product of expression of a gene that was mutated.
Why do people get Adenomatous Polyposis Coli?
APC is usually associated with inheritance of a faulty gene from a parent. The APC gene is required to stop cells growing too fast: knocking out the other copy of the gene in the body (by chemical damage or random DNA damage) removes this 'brake' and allows lots of little polyps to form in the intestine.
Does FAP follow a recessive or dominant inheritance pattern and why?
FAP follows both an autosomal recessive and autosomal dominant pattern depending on which gene you inherit the disease from. If inherited through the APC gene, which is most common, it is autosomal gdthe disease. If inherited through the MUTYH gene it is autosomal recessive, meaning that both parents were carriers of the disease or they both were living with the disease.
In some types of colon cancer stem cells have a mutation in the APC gene. What happens if the APC gene is mutated?
When the APC gene is mutated, it disrupts the normal regulation of cell growth and division in the colon. APC normally acts as a tumor suppressor, helping to control the Wnt signaling pathway, which is crucial for maintaining proper cell function. A mutation can lead to uncontrolled cell proliferation, contributing to the development of benign polyps and, ultimately, colorectal cancer. This mutation is a key early event in the progression of certain types of colon cancer.
What is a changed gene?
mutated
What most mutated genes are which cause human disorders?
A mutated gene is just a gene that doesn't have the correct DNA or alleles.. Depending of the human disorder the gene that is mutated will be different... We use genes throughout our bodies but ALL genes can cause human disorders but there is NO single gene that, when mutated, creates ALL genetic modification...
Why are most mutations in eukaryotes recessive?
Most mutations in eukaryotes are recessive because they typically involve changes in a single gene, and the presence of a normal copy of the gene can often mask the effects of the mutated gene. This means that the mutated gene is only expressed when both copies of the gene are mutated, resulting in a recessive trait.
How can mutation in gene lead to a new trait in an organism?
The mutated gene codes for a protein that cause a new trait
What is muteins?
protein that is a product of expression of a gene that was mutated.
What is apc?
APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor.
What is the new mRNA stand produced by this mutated gene?
The specific sequence of the new mRNA strand produced by a mutated gene will depend on the nature of the mutation. Mutations can cause changes in the coding region of the gene, leading to alterations in the mRNA sequence and potentially affecting the resulting protein or gene function. Further analysis and sequencing of the mutated gene would be required to determine the exact mRNA sequence.
Why do people get Adenomatous Polyposis Coli?
APC is usually associated with inheritance of a faulty gene from a parent. The APC gene is required to stop cells growing too fast: knocking out the other copy of the gene in the body (by chemical damage or random DNA damage) removes this 'brake' and allows lots of little polyps to form in the intestine.
Does FAP follow a recessive or dominant inheritance pattern and why?
FAP follows both an autosomal recessive and autosomal dominant pattern depending on which gene you inherit the disease from. If inherited through the APC gene, which is most common, it is autosomal gdthe disease. If inherited through the MUTYH gene it is autosomal recessive, meaning that both parents were carriers of the disease or they both were living with the disease.
What can cause a mutated gene?
# UV light # carcinogenics # heat # viruses
What name is given to someone who has a gene for a recessive genetic disorder but does not have the disorder?
Someone who has a gene for a recessive genetic disorder but does not exhibit the disorder is referred to as a "carrier." Carriers possess one copy of the mutated gene and one normal gene, which means they can pass the mutated gene to their offspring without showing symptoms of the disorder themselves.
