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Once pyruvate is transported into the mitochondrion, it undergoes decarboxylation, where one carbon atom is removed and released as carbon dioxide (CO2). This process is catalyzed by the pyruvate dehydrogenase complex, and the remaining two-carbon molecule, acetyl-CoA, is formed. Acetyl-CoA then enters the citric acid cycle (Krebs cycle) for further energy production. Additionally, during this conversion, NAD+ is reduced to NADH, which carries electrons to the electron transport chain for ATP synthesis.

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1w ago

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