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Oxygen (O2) is the electron acceptor in the Electron Transport Chain.

"The electrons are passed to O2, the final electron acceptor of the electron transport system. This oxygen, now negatively charged because it has acquired additional electrons, combines with H+ ions, which are positively charged because they donated electrons at the beginning of the electron transport system, to form H2O." (Sherwood 36)

References:

Sherwood, Lauralee. Human Physiology: from Cells to Systems. 7th ed. Australia: Brooks/Cole, Cengage Learning, 2010. Print.

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