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What is an acylcarnitine?

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∙ 9y ago

Updated: 11/19/2022

An acylcarnitine is an ester of carnitine and a carboxylic acid.

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How do the carnitine shuttles work?

The carnitine shuttles help transport fatty acyl coA from the cytosol of the cell into the mitochondrial matrix. The acyl group is first transfered to a carnitine and it is catalyzed into fatty acyl-carnitine by carnitine acyltransferease I at the outer mitochondrial membrane. The fatty acyl-carnitine then moves through the intermembrane space of the mitochondria through the transporter carnitine-acylcarnitine translocase. When the acyl group reaches the matrix, it is transferred to mitochondrial CoA, it is catalyzed by carnitine acyltransferase II to reform fatty acyl CoA. The carnitine is regenerated and it moves back to the intermembrane space with the aid of the same transporter.

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