An antisense is a molecule which interacts with a complementary strand of nucleic acids, so as to suppress its transcription.
antisense mRNA
The template strand is also referred to as the antisense strand because its sequence is complementary to the mRNA transcript that is eventually produced during transcription. While the mRNA transcript is in the sense orientation with codons that can be translated into proteins, the template strand is read in the antisense orientation to ensure accurate base pairing during transcription.
Antisense technology is based on stopping the production of a protein. In order for a protein to be formed, the mRNA has to be translated (read by the ribosomes). The happens in the cytoplasm. There are stretches of nucleic acid bases called cDNA that are complimentary to specific mRNA sequences. These cDNA molecules can bind to the mRNA molecules and inactivate them. When mRNA is inactivated, it cannot be translated into a protein and a protein will not be formed. Since every protein is made by a certain mRNA, by inactivating the mRNA using cDNA molecules, the production of the protein can be stopped. This process is called mRNA silencing or antisense technology
lets take this section of DNA ATAGCCATA DNA polymerase codes for the antisense (not mirror) strand. this would be TATCGGTAT
siRNA refers to a small interfering RNA or sometimes known as short interfering RNA or silencing RNA. It a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. The most notable role of siRNA is its involvement in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene.whereas Antisense RNA is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell.
antisense
antisense mRNA
antisense technology or degradation
Millennium - 1996 I Sense and Antisense 2-3 was released on: USA: 3 October 1997
Millennium - 1996 I Sense and Antisense 2-3 is rated/received certificates of: Argentina:16
Stanley T. Crooke has written: 'Therapeutic applications of oligonucleotides' -- subject(s): Therapeutic use, Oligonucleotides 'Antisense Research and Application' 'Antisense Drug Technology'
The template strand is also referred to as the antisense strand because its sequence is complementary to the mRNA transcript that is eventually produced during transcription. While the mRNA transcript is in the sense orientation with codons that can be translated into proteins, the template strand is read in the antisense orientation to ensure accurate base pairing during transcription.
deficiency, lack, insufficiency, need, dearth
The sense strand of DNA is the strand that has the same sequence as the mRNA that is transcribed from DNA. The antisense strand is the complementary strand of the sense strand, which is used as a template for mRNA synthesis. The mRNA is transcribed from the antisense strand and contains the same sequence as the sense strand.
The term for the 3' to 5' strand of DNA is the "antisense strand."
An asRNA is an antisense RNA, a single-stranded RNA which is complemenetary to a messenger RNA strand transcribed within a cell.
Antisense technology can impact cells by interfering with the expression of specific genes, leading to reduced protein production and altered cellular functions. It can be used to selectively inhibit the expression of disease-causing genes, making it a potential tool for therapeutic interventions in various diseases. Additionally, antisense technology can help in understanding the role of specific genes in cellular processes.