Do you mean Encephalitis? Or Anencephaly? I'll explain them both, and you can just skip the one that you didn't mean.
Encephalitis is acute inflammation of the brain. It can be caused by viral/bacterial infections, auto-immune disease, HSV, the later stages of Syphilis, Rabies, Parasitic/Protozoal infections, etc. There's a variety of different causes.
Anencephaly is a very serious birth defect in which a baby is born without parts of the brain/skull. If you Google images 'Anencephaly' be warned that the images ae very disturbing. It happens when the neural tube (The neural tube is responsible for forming the brain/skull amongst other things) closes up before the brain/skull is fully developed.