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What happens with demyelination and denervation?

Demyelination is the loss of the protective covering (myelin sheath) around nerve fibers, which can lead to impaired nerve conduction. Denervation refers to the loss of nerve supply to a particular muscle or organ, which can result in muscle weakness or dysfunction. Both conditions can lead to a variety of neurological symptoms depending on the location and extent of the damage.


What is Without evidence of active denervation?

Without evidence of active denervation refers to a clinical or diagnostic finding indicating that there are no signs of ongoing nerve damage or dysfunction in a patient. This means that nerve signals are likely intact and functioning normally, as there is no indication of muscle atrophy or weakness due to nerve injury. This phrase is often used in electromyography (EMG) reports or neurological assessments to clarify the status of nerve health. In the absence of active denervation, other conditions may need to be considered for any symptoms a patient is experiencing.


What is the neuronal basis of denervation hypersensitivity?

Denervation hypersensitivity occurs in multiple sclerosis. In multiple sclerosis demyelination of oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system result in disruption of communication between upper motor neurons in the brain and the lower motor neurons in the gray matter of the spinal cord. The end result is denervation hypersensitivity with physical symptoms of increased muscle tone, difficulty controlling muscles, exaggerated reflexes, and muscle spasms.


What does disuse mean?

disuse means: no longer in use, obsolete. It can also refer to neglect please see related link


Can adaptation s occur throuh use and disuse?

Yes, the concept of adaptation through use and disuse was proposed by Jean-Baptiste Lamarck. He suggested that organisms could pass on acquired traits from use or disuse of certain organs to their offspring. However, this idea has been largely discredited in modern biology, as adaptation is primarily driven by natural selection acting on genetic variations.