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The net charge of collagen varies depending on its specific type and the pH of the surrounding environment. Collagen contains various amino acids, some of which are charged, such as lysine and arginine (positively charged) and aspartic and glutamic acids (negatively charged). At physiological pH (around 7.4), collagen generally has a net neutral to slightly negative charge due to the predominance of negatively charged amino acids. However, the exact charge can fluctuate with changes in pH and ionic conditions.

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