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A mutation is a genetic change that has occurred in an individual organism. (e.g. an A is changed to a G in a cell of an organism.)

A polymorphism is the existence of multiple genetic varieties within a population. (e.g. At a particular place in the genome, some organisms within a population have A's and other organisms within the population have G's.)

Note:

1. Mutations and polymorphisms can be advantageous, deleterious, or neutral.

2. All polymorphisms began their existence as mutations. A mutation always occurs in an individual, but can become a polymorphism if it is heritable (i.e. if the mutation affected the germ line) and if it succeeds in spreading through a significant proportion of the population.

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