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There are several ways to interpret the question. For some, the first line of defence is the skin since it acts as an impermeable barrier and also has antibacterial properties due to the acids secreted and normal bacteria fauna on the skin. However, since most pathogens, being capable of causing disease, can inherently overcome the skin defense, the first line of immune defence is the innate immune system that exists in the tissues underlying epithelia (skin or any mucous membranes). The innate immune system has cells that can recognize and destroy pathogens without specificity.

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16y ago

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