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Membranes differ in type but they are all fundamentally made up of phospholipids and work on the principle of self assembly through hydrophobic and hydrophilic interactions with water.

A phospholipid is a molecule that has a charged (or polar) head group that includes phosphate ions (hence the phospho.. bit). These head groups are polar in the same way that water molecules are polar, hence the head groups are attracted to water (hydrophilic).

The tail of a phospholipid is made up of one or two long hydrocarbon chains which are not polar, and hence repel water and attract to themselves (hydrophobic).

So a phospholipid is ambiphilic, ie. simulatenously hydrophobic and hydrophilic.

If I were to draw it @ = headgroup I = hydrocarbon chain

@

II

If you put a large concentration of these molecules in water, the tails will clump together and the polar head groups will point outwards facing the water. A membrane is therefore a double layered sheet of phosholipids that self assemble into double layered membranes:

(water)

@@@@@@@@@@@@@@@@@@@@

IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII

IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII

@@@@@@@@@@@@@@@@@@@@

(water)

these membranes can then have membrane proteins spanning the membrane to act as gateways in and out of the cell. For example KCSA is a potassium ion channel used during nerve signalling.

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