Phenylketonuria is an autosomal recessive genetic disorder. This means that an individual must inherit two copies of the defective gene (one from each parent) in order to develop the condition.
Multiple factor inheritance
Autosomal recessive inheritance usually skips a generation. This occurs when both parents are carriers of a recessive gene and pass it on to their offspring, who may then express the trait.
It is possible for a parent with phenylketonuria to pass the condition to their offspring if both parents are carriers of the PKU gene mutation. In this case, there is a 25% chance that their child will inherit two copies of the mutated gene and develop phenylketonuria. Genetic testing can provide more information on the risk of passing PKU to offspring.
A person with phenylketonuria (PKU) is unable to break down the amino acid phenylalanine due to a deficiency in the enzyme phenylalanine hydroxylase. This can lead to a build-up of phenylalanine in the body, which can be toxic to the brain and nervous system if not controlled through dietary restrictions.
To analyze a pedigree chart, start by noting patterns of inheritance for a specific trait or disease. Look for how the trait is passed through generations and whether it appears to follow a dominant, recessive, or X-linked pattern. Pay attention to any affected individuals, their relationships, and their offspring to understand the mode of inheritance and risk of passing on the trait.
codominant alleles
The mode of inheritance (e.g., autosomal dominant, autosomal recessive) determines the likelihood of passing on a genetic trait to offspring and influences the probability of inheritance in a family. Understanding the mode of inheritance is crucial in predicting the risk of inheriting a specific trait or disorder, as well as in genetic counseling and family planning. Inheritance patterns can be more easily analyzed and predicted when the mode of inheritance is known, aiding in the identification and management of genetic conditions within families.
phenylketonuria
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phenylketonuria
Autosomal recessive.
Polygenic inheritance is the least prevalent mode of inheritance because it involves multiple genes contributing to a single trait and is influenced by environmental factors, making it more complex and less common than other simpler modes like Mendelian inheritance.
autosomal recessive
2.42% of the world's population has Phenylketonuria (pku)
Phenylketonuria
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PKU