Hemophilia is passed down from mother to son. It is extremely
rare for a woman to have hemophilia. It is necessary, though, for
a woman to be a carrier of the disorder for her son to acquire this
disorder. Females have two X chromosomes whereas males only
have one. When a boy is born, he takes one X chromosome from
his mother and one Y chromosome from his father. Therefore, he
can only get hemophilia through his mother.
Example One:
Mother(Carrier)+Father(Non-Affected)=50% chance of their son
acquiring the disorder and 50% chance of their daughter being a
carrier.
Example Two:
Mother(Non-Affected)+Father(Hemophiliac)=All sons will be
non-affected and all daughters will be carriers.
There are no hard answers to this, it depends strictly on luck. The statistics are though not very good for their children. Statisically the couple have a chance of having a normal son, a daughter that is a carrier for hemophilia, a daughter with hemophilia and a son with hemophia.
The woman's father being unaffected means that he does not carry the gene for hemophilia on his X chromosome. Therefore, the woman does not have the gene and cannot pass it on to her son. Her son will not inherit hemophilia from his uncle.
Almost certainly no. Hemophilia cannot be passed from father to son. There is a very slight chance (almost incalculable) that a spontaneous mutation can take place and thus make the son turn out to be a hemophiliac himself. Using the the best guess from the CDC, nearly 1/3 of hemophiliacs are the result of a random mutation. the statistic of 1 in 5000 male births is also a CDC statistic, this would imply that the son would have approximately a 1 in 15,000 chance of having hemophilia and his father's genetics would have nothing to do with it. Men and women each have 23 pairs of chromosomes. Women have two X chromosomes; men have one X and one Y chromosome. Hemophilia is an X-linked genetic disorder, which means that it's passed from mother to son on the X chromosome. If the mother carries the gene for hemophilia on one of her X chromosomes, each of her sons will have a 50% chance of having hemophilia. Hemophilia affects mostly boys, although it's very rare: Only about 1 in every 5,000 boys is born with it. The disease can affect people of any race or nationality.
First of all, Spontaneous mutations account for 1/3 of the cases of genetic hemophilia. This means that 1 out of 3 people born with hemophilia have no family history of the trait prior to that person. In the scenario you are describing, you are assuming that there was a carrier when in fact, there is a good chance that there was not. There is also a chance that the child born with hemophilia received the mutation from his mother. Frequently women will have the mutation on one X chromosome but not their second. Depending od the individual case, the mother could carry the gene but not be symptomatic. It is impossible for the son to have received the gene from his father. Since in order for a boy to actually be a boy, he must receive his father's Y chromosome and not his X chromosome, a son cannot receive the affected X chromosome from his father. Also, in order for a father to pass the trait on through daughters, the father himself would be a hemophiliac.
If both parents have x-linked hemophilia, the father's genotype would be XhY and the mother's genotype would be XhXh, which is astronomically rare. If this did happen, all of their children would inherit x-linked hemophilia. Hemophilia is passed down from mother to son. It is extremely rare for a woman to have hemophilia. It is necessary, though, for a woman to be a carrier of the disorder for her son to acquire this disorder. Females have two X chromosomes whereas males only have one. When a boy is born, he takes one X chromosome from his mother and one Y chromosome from his father. Therefore, he can only get hemophilia through his mother. Example One: Mother(Carrier)+Father(Non-Affected)=50% chance of their son acquiring the disorder and 50% chance of their daughter being a carrier. Example Two: Mother(Non-Affected)+Father(Hemophiliac)=All sons will be non-affected and all daughters will be carriers.
There are no hard answers to this, it depends strictly on luck. The statistics are though not very good for their children. Statisically the couple have a chance of having a normal son, a daughter that is a carrier for hemophilia, a daughter with hemophilia and a son with hemophia.
50
50
Without any further information, the probability is between 0.0001 and 0.0002
50%
1: 4000 to 1: 5000 males
50%
0% probability that their daughter will have it because it is a X-linked disease meaning only males can get it.
The woman's father being unaffected means that he does not carry the gene for hemophilia on his X chromosome. Therefore, the woman does not have the gene and cannot pass it on to her son. Her son will not inherit hemophilia from his uncle.
Rasputin healed the Czar's son's illness (hemophilia)
Hemophilia is a X linked recessive disorder. Usually the mother is an unaffected carrier and her son unfortunately receives the X chromosome in which hemophilia is linked to.
50%