Hemophilia is a X linked recessive disorder. Usually the mother is an unaffected carrier and her son unfortunately receives the X chromosome in which hemophilia is linked to.
Hemophilia is typically an X-linked recessive condition. If a mother has hemophilia, she carries two copies of the hemophilia allele on her X chromosomes (since females have two X chromosomes). Therefore, any male offspring will inherit one of her X chromosomes, which will carry the hemophilia allele, leading to him being affected by the condition. The male will inherit his Y chromosome from his father, which does not carry the hemophilia gene.
The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
Sex-linked genes
the X chromosome
The genes associated with Hemophilia A and B are located on the X chromosome, which is one of the 2 sex chromosomes. For males, who have only 1 X chromosome, 1 altered copy of the gene in each cell is sufficient to cause hemophilia. In females, who have 2 X chromosomes, a mutation would have to occur in both copies of the gene to cause hemophilia. Since it is unlikely that females will have 2 altered copies of this gene it is therefor very rare for females to have hemophilia.
The X chromosome. That's why it's more common in males; females have 2 X chromosomes, but males only have 1. So if a woman has the hemophilia mutation on one of her chromosomes, she probably won't be affected by it.
A carrier for hemophilia is a female who carries the genetic mutation for hemophilia on one of her X chromosomes, but does not exhibit symptoms of the condition herself. Carriers can pass on the gene mutation to their children, resulting in hemophilia in male offspring. Testing can confirm carrier status.
hemophilia
when does the duplication of chromosomes occur?
No, hemophilia is not caused by having too many chromosomes. It is a genetic disorder primarily linked to mutations in specific genes responsible for blood clotting, particularly the F8 gene (hemophilia A) or the F9 gene (hemophilia B), both located on the X chromosome. Hemophilia is typically inherited in an X-linked recessive manner, meaning it mainly affects males while females can be carriers. Chromosomal abnormalities, such as having an extra chromosome, do not directly cause hemophilia.
The gene for hemophilia A is found on the X chromosome (it is a sex-linked recessive disorder). Women have two X chromosomes and men have one X chromosome. A woman with hemophilia (very rare) would have the mutated gene on both of her X chromosomes. This means that all of their children, both male and female would have hemophilia.
Since Hemophilia A is an "X Chromosome" disease and women have two "X" Chromosomes, women with only one "X" Chromosome with the disorder would be carriers of the disease but not affected by it. Women with both "X" Chromosomes with the disorder would be very rare.