The X chromosome. That's why it's more common in males; females have 2 X chromosomes, but males only have 1. So if a woman has the hemophilia mutation on one of her chromosomes, she probably won't be affected by it.
A woman carrying a gene for hemophilia is typically a carrier with one X chromosome carrying the hemophilia gene and one X chromosome carrying the normal gene. When she is mated with a normal male who has one X chromosome and one Y chromosome, there is a 50% chance that the son will inherit the X chromosome carrying the hemophilia gene from the mother. Since males have only one X chromosome, if they inherit the hemophilia gene, they will express the disorder.
Because hemophilia is a disease linked to a recessive gene on the X-chromosome, females have another X-chromosome to block out the diseased one. However, males have only one X-chromosome, so they are more often subject to hemophilia.
the X chromosome
Her father has to have hemophilia as well, and the mother is a carrier or also has hemophilia. So if we pretend that the hemophilia gene is "x", you need to have "xx" to have hemophilia. The father must have the genotype "Yx" and the mother has the have "Xx" or "xx".
Because the gene that causes hemophilia is located on the X chromosome, so it will occur in males more frequently than in females.
Hemophilia is most often caused by mutations in the F8 gene, located on the X chromosome. This gene provides instructions for making a protein called factor VIII, which is essential for blood clotting. Mutations in the F8 gene can result in reduced or absent levels of factor VIII, leading to the characteristic bleeding problems seen in hemophilia.
chromosome 1 chromosome 1
There are no hard answers to this, it depends strictly on luck. The statistics are though not very good for their children. Statisically the couple have a chance of having a normal son, a daughter that is a carrier for hemophilia, a daughter with hemophilia and a son with hemophia.
Males only have one copy of the X chromosome
Since the gene for Hemophilia is carried on the X chromosome and males pass only their Y chromosome onto their sons, no their sons should not have hemophilia. Of course all daughters of a male with hemophilia will be carriers of the mutation since they with receive his X chromosome, not the Y.
Queen Victoria had four sons Albert Edward Arthur Alfred Leopold The reason why Albert Edward, Arthur and Alfred did not display hemophilia is because they did not have it. Hemophilia is a sex linked gene. Leopold got hemophilia because Victoria carried the gene. She had one healthy X chromosome and an X that had the gene for hemophilia. Leopold got the X with hemophilia and the other boys got the healthy X chromosome
Yes, hemophilia is typically more common in males than in females. This is because the gene for hemophilia is located on the X chromosome, and males only have one X chromosome. In females, who have two X chromosomes, one healthy gene can compensate for the faulty gene, reducing the chances of exhibiting symptoms.