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Acetyl CoA is completely broken down into carbon dioxide, hydrogen ions, and electrons during the process of cellular respiration, specifically in the Krebs cycle (also known as the citric acid cycle). This cycle occurs in the mitochondria and is part of aerobic respiration, where acetyl CoA is oxidized to produce energy-rich molecules such as NADH and FADH2, which are then used in the electron transport chain to generate ATP.

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