The gene associated with sickle cell anemia is HBB, which is located in region 15.5 on the short arm of chromosome 11. There are many variations that can cause sickle cell, but primarily it is caused by the hemoglobin variant Hb S. According to the human genome project website: "the hydrophobic amino acid valine takes the place of hydrophilic glutamic acid at the sixth amino acid position of the HBB polypeptide chain. This substitution creates a hydrophobic spot on the outside of the protein structure that sticks to the hydrophobic region of an adjacent hemoglobin molecule's beta chain. This clumping together (polymerization) of Hb S molecules into rigid fibers causes the "sickling" of red blood cells." In a nutshell, when the hydrophobic (water fearing) amino replaces a hydrophilic one (water loving) on the protein chain, it creates a spot that sticks to another similar mutated gene, and they clump together, creating a sickle shaped cell. Looking at the location and incidence rates of sickle cell amenia, scientists believe that because malaria rates are high in the region, the body has created this defense against the disease -- an evolutionary self defense. Hope that helps :-)
A certain substitution in human DNA changes the code for hemoglobin; this ultimately results in sickle-cell anima.
sickle cell anemia is releated with RBC . RBC will change in size ( microcytic ) and shap will change (sickling shap) that are cause in blokers vascular > then cause hypoxia in some organes that is cause tachycardia and shortness breath some time palor
Folic acid helps the body make red blood cells and can improve the symptoms of anemia by supporting the production of healthy red blood cells. However, folic acid supplements will not directly affect the underlying cause of sickle cell anemia, which is a genetic disorder affecting hemoglobin.
Thalassemia is a quantitative problem of too few globins synthesized, whereas sickle-cell anemia (a hemoglobinopathy) is a qualitative problem of synthesis of an incorrectly functioning globin. (wikipedia)
They are definitely not the same. If you are looking for an answer to WHY sickle-cell anaemia is BENEFICIAL to those with malaria then follow this link,What_is_the_benefit_of_sickle_cell_anemia_to_Africans_with_malaria
Genetics
No.
no it dose not sickle cell anemia causes death only if African Americans
No, drug test look for specific chemicals.
Mutations in the hemoglobin molecules cause sickle cell anemia.
yes
Sickle cell anemia.
Sickle cell anemia.
A certain substitution in human DNA changes the code for hemoglobin; this ultimately results in sickle-cell anima.
Yes
C. Sickle-cell anemia
sickle cell anemia is releated with RBC . RBC will change in size ( microcytic ) and shap will change (sickling shap) that are cause in blokers vascular > then cause hypoxia in some organes that is cause tachycardia and shortness breath some time palor