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Diuretics primarily affect the structures of the nephron known as the renal tubules, specifically the proximal convoluted tubule, the loop of Henle, and the distal convoluted tubule. Loop diuretics, for example, target the ascending limb of the loop of Henle, while thiazide diuretics act on the distal convoluted tubule. By inhibiting sodium reabsorption in these areas, diuretics increase urine output and reduce fluid retention.

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6d ago

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