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A silent mutation has the least effect on an organism. It is when the codon is changed to the same amino acid.

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What is a mutation called that has no effect on an organism?

A point mutation, in which one nitrogen base in a codon is substituted for another, may have no effect on an organism. This is true if the base substitution does not change the amino acid that the codon represents, or if the mutation occurs in a non-critical location in the protein so that the protein's structure is not changed significantly and the protein is still able to function.


When is a single base substitution mutation least likely to be deleterious?

A single base substitution mutation is least likely to be deleterious when it occurs in a non-coding region of DNA, such as in an intron or in a region with no functional significance. Additionally, if the mutation results in a silent or synonymous change in the amino acid sequence, it may not have a noticeable effect on the protein's function.


Which type of mutation causes the most change to the protein produced?

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