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What would the effect on translation be of a single base pair deletion in an organism's DNA?
Assuming that the deletion occurs somewhere in the protein coding region of an organism's DNA - that is any where within it's Genome excluding introns and other non-expressed regions - :
mRNA sequence (transcribed from DNA) is translated into protein using triplet - codons, meaning that three consecutive nucleotide bases code for one amino acid (a building block of the protein chain). For example:
UUU CCU CAA A.... (nucleotides) codes for
Phe Pro Asn ... (3 letter abbr. for amino acids). Now, if the first nucleotide gets deleted, we get:
UUC CUC AAA that translates into:
Phe Leu Lys .
What happens is that triplets shift to the right by one nucleotide and that changes the meaning of all triplets that follow resulting in a protein with a different amino acid composition [sequence] that almost for certain has lost its intended function or even becomes damaging to the organism - these are rarely beneficial due to the following: these are called Frame-Shift mutations and you are quite right they usually have quite a deleterious effect.
What else can I help you with?
Strategy for Single cross over and double cross over in gene deletion?
In single crossover gene deletion strategy, a linear DNA fragment with homology to the target gene is introduced, leading to recombination and deletion of the gene. In double crossover strategy, two DNA fragments are introduced flanking the target gene, leading to recombination events resulting in gene deletion. Double crossover strategy is more precise and can avoid potential off-target effects compared to single crossover strategy.
Bacteria are single celled organisms?
yes bacteria is a single celled organisms.
Is bacteria single or multicellular?
Usually Bacteria is unicellular, but in some cases multicellular.
What is the smallest number of nucleotides that must be added or subtracted to alter the reading frame?
The smallest number of nucleotides that must be added or subtracted to alter the reading frame is 1. A single nucleotide insertion or deletion can cause a frameshift mutation, resulting in a different reading frame for translation.
How do multicellular organisms begin?
multicellular organisms begin as a single cell.
What is the plural of deletion?
You can have a single deletion or many deletions.
What effect does a high level of UV light have on phytoplankton?
the UV light kills single-celled organisms
What effect does high levels of UV light have on phytoplankton?
the UV light kills single-celled organisms
A involves the addition or deletion of a single base in a DNA molecule.?
A Frameshift mutation
What are single organisms?
well I don't know about single organisms but single celled organisms are of coarse organisms with only one cell
Which mutation results in a single missing letter in the genetic code?
frameshift mutation: deletion
Strategy for Single cross over and double cross over in gene deletion?
In single crossover gene deletion strategy, a linear DNA fragment with homology to the target gene is introduced, leading to recombination and deletion of the gene. In double crossover strategy, two DNA fragments are introduced flanking the target gene, leading to recombination events resulting in gene deletion. Double crossover strategy is more precise and can avoid potential off-target effects compared to single crossover strategy.
Are the oldest known and simplest organisms?
The oldest known and simplest organisms are part of the Archaebacteria kingdom. Members of this kingdom are one celled organisms and are also the most ancient organisms.
Bacteria are single celled organisms?
yes bacteria is a single celled organisms.
What is a group of single celled organisms?
what is the group of mainly single celled organisms called
Generally are single celled organisms?
Amoebas are single celled organisms. They do not have any particular shape. Another group of single-celled organisms like amoebas are protists.
Are you single in spanish translation?
¿Estás soltero? (or soltera if you're speaking to a woman)
