In liver
Hemophilia is caused by a deficiency of clotting factor VIII (hemophilia A) or clotting factor IX (hemophilia B).
Factor VIII is crucial in the intrinsic pathway of the blood coagulation system. It helps in the activation of factor X, which is a key step in the formation of a blood clot. Without factor VIII, this pathway would be impaired, leading to difficulties in clot formation.
To determine the expression pattern of the Factor VIII gene, techniques such as quantitative PCR (qPCR) or RNA sequencing (RNA-seq) can be employed. These methods allow for the quantification of mRNA levels, revealing how and when the Factor VIII gene is expressed in different tissues or under various conditions. Additionally, in situ hybridization can visualize the spatial expression of the gene within tissues. Collectively, these techniques provide insights into the regulation and functional significance of Factor VIII in hemostasis.
The absence of Factor VIII is indicative of hemophilia A, a genetic bleeding disorder where the blood does not clot properly. This can lead to prolonged bleeding episodes and difficulty stopping bleeding after injury or surgery.
Hemophilia is most often caused by mutations in the F8 gene, located on the X chromosome. This gene provides instructions for making a protein called factor VIII, which is essential for blood clotting. Mutations in the F8 gene can result in reduced or absent levels of factor VIII, leading to the characteristic bleeding problems seen in hemophilia.
Hemophilia is caused by a deficiency of clotting factor VIII (hemophilia A) or clotting factor IX (hemophilia B).
No Factor VIII is Antihemophilic factor.Thrombocytopenia is a low platlet count Thrombocyte = platlet Penia = poorness
i want know price factor viii
Hemophilia
No,All are made in the liver except for Factor VIII (made by the vascular endothelium) and vonWillebrand's factor which is made in the endothelium (in the Weibel-Palade bodies), megakaryocytes (α-granules of platelets), and subendothelial connective tissue.
Factor VIII is crucial in the intrinsic pathway of the blood coagulation system. It helps in the activation of factor X, which is a key step in the formation of a blood clot. Without factor VIII, this pathway would be impaired, leading to difficulties in clot formation.
factor VIII deficienty
50 usd
about 1500 pounds
Hemophilla is a genetic disorder in which there is absence of clotting factor viii, leading to defective clot formation, petechiae bruising and gum bleeding. Treatment is by injecting factor VIII concentrate
A: Treatment of hemophilia involves replacement of factor VIII chronically, with additional doses administered during phases of acute bleeding. Patients with mild hemophilia A can sometimes be treated with a synthetic hormone called desmopressin. Desmopressin stimulates the release of the carrier for factor VIII, thus causing increases in blood concentration of factor VIII.
To determine the expression pattern of the Factor VIII gene, techniques such as quantitative PCR (qPCR) or RNA sequencing (RNA-seq) can be employed. These methods allow for the quantification of mRNA levels, revealing how and when the Factor VIII gene is expressed in different tissues or under various conditions. Additionally, in situ hybridization can visualize the spatial expression of the gene within tissues. Collectively, these techniques provide insights into the regulation and functional significance of Factor VIII in hemostasis.