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What is eudragit?
Eudragit is a brand name for a type of polymer used in pharmaceutical formulations. It is often used as a coating for tablets to control drug release and improve stability. Eudragit polymers come in various types with different properties to suit the specific needs of a formulation.
What are polymers as capsules?
When a negatively charged polymer and a positive polymer get close enough, they will arrange themselves around each other.The dye to be released is trapped inside the polymersThe polymer layers form a barrier which prevents the drug from being dissolved before it reaches the target organThe release of drug can be controlled by the charge and number of polymer chains in the capsule
What is higuchi model?
The Higuchi model is a mathematical model used in pharmacokinetics to describe drug release from a controlled-release formulation. It is based on Fick's second law of diffusion and describes drug release as a function of the square root of time. The model is commonly used to analyze drug release kinetics from matrix systems.
What is solid dispersion?
Solid dispersion is a technique used in pharmaceutical formulation to increase the solubility and bioavailability of poorly water-soluble drugs. It involves dispersing the drug within a solid carrier matrix, often a polymer, to enhance its dissolution properties. This process helps to improve the drug's absorption and effectiveness in the body.
What is lipid formulation?
Lipid formulation refers to the incorporation of lipids (fats) into pharmaceutical formulations to enhance the solubility and bioavailability of poorly soluble drugs. Lipid formulations can improve drug delivery, absorption, and efficacy, particularly for drugs with low aqueous solubility. They are commonly used in the development of liposomal drug delivery systems and lipid-based drug formulations.
If a standard injectable form of a drug is given every 12 hours is the sustained release form more likely to be given every 6 hours or 96 hours?
More likely would be every 96 hours - the sustained release form is the formulation that keeps blood levels of the drug elevated for longer periods of time than the standard formulation.
What is matrix tablet?
Matrix tablet is a specific formulation intended for slow/controlled/sustained release of drug at a desired location in gastro-intestinal tract.
Formulation of sustained release rectal suppository?
The formulation of sustained-release rectal suppositories involves selecting appropriate excipients that facilitate prolonged drug release while ensuring stability and bioavailability. Commonly used bases include hydrophilic polymers (e.g., polyethylene glycol) or lipid-based carriers (e.g., cocoa butter) that can control the release rate. Active pharmaceutical ingredients are usually combined with these bases, and additives like stabilizers or surfactants may be included to enhance solubility and absorption. The final formulation is then shaped into suppository molds and evaluated for consistency, release profile, and efficacy.
What are the factors influencing oral sustained- release dosage form design?
Factors influencing oral sustained-release dosage form design include drug properties (such as solubility, stability, and half-life), desired release profile, site of absorption in the gastrointestinal tract, manufacturing feasibility, patient compliance, and regulatory requirements. Additionally, considerations such as cost-effectiveness, formulation complexity, and technology advancement may also impact the design of sustained-release dosage forms.
What is eudragit?
Eudragit is a brand name for a type of polymer used in pharmaceutical formulations. It is often used as a coating for tablets to control drug release and improve stability. Eudragit polymers come in various types with different properties to suit the specific needs of a formulation.
How are mixtures important in food and drug formulation?
a mixture is important in food and drug formulation with food chain
What is the mechanism in a pill to dispense an active substance or drug to the body over a sustained period?
time release
What are polymers as capsules?
When a negatively charged polymer and a positive polymer get close enough, they will arrange themselves around each other.The dye to be released is trapped inside the polymersThe polymer layers form a barrier which prevents the drug from being dissolved before it reaches the target organThe release of drug can be controlled by the charge and number of polymer chains in the capsule
What is higuchi model?
The Higuchi model is a mathematical model used in pharmacokinetics to describe drug release from a controlled-release formulation. It is based on Fick's second law of diffusion and describes drug release as a function of the square root of time. The model is commonly used to analyze drug release kinetics from matrix systems.
Definition of novel drug delivery system?
It is advance drug delivery system which improve drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue
How you can calculate the maintenance dose in the formulation of controlled release tablets?
Dt = Dose (1 + 0.693 × t/t1/2) Where, Dt = Total dose, Dose = Immediate release dose, t = Total time period for which sustained release is required, t1/2 = Half-life of drug.
What is preformulation studies?
Preformulation studies involve the physicochemical characterization of a drug substance in preparation for formulation development. These studies help in understanding the drug's solubility, stability, compatibility with excipients, and other factors that can impact its formulation. Overall, preformulation studies provide critical information that guides the formulation process for drug development.
