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What is eudragit?
Eudragit is a brand name for a type of polymer used in pharmaceutical formulations. It is often used as a coating for tablets to control drug release and improve stability. Eudragit polymers come in various types with different properties to suit the specific needs of a formulation.
What are polymers as capsules?
When a negatively charged polymer and a positive polymer get close enough, they will arrange themselves around each other.The dye to be released is trapped inside the polymersThe polymer layers form a barrier which prevents the drug from being dissolved before it reaches the target organThe release of drug can be controlled by the charge and number of polymer chains in the capsule
What is higuchi model?
The Higuchi model is a mathematical model used in pharmacokinetics to describe drug release from a controlled-release formulation. It is based on Fick's second law of diffusion and describes drug release as a function of the square root of time. The model is commonly used to analyze drug release kinetics from matrix systems.
What is solid dispersion?
Solid dispersion is a technique used in pharmaceutical formulation to increase the solubility and bioavailability of poorly water-soluble drugs. It involves dispersing the drug within a solid carrier matrix, often a polymer, to enhance its dissolution properties. This process helps to improve the drug's absorption and effectiveness in the body.
Pharmaceutical importance of carbohydrates?
The pharmaceutical importance of carbohydrates cannot be overstated, as these organic compounds play crucial roles in various aspects of drug formulation, delivery, and efficacy. Despite often taking a backseat to proteins and fats in discussions of pharmaceuticals, carbohydrates are indispensable components with unique properties that pharmaceutical scientists leverage to enhance therapeutic outcomes. One primary role of carbohydrates in pharmaceuticals is as excipients in drug formulations. Excipients are inert substances added alongside active pharmaceutical ingredients (APIs) to facilitate drug delivery, stability, and bioavailability. Carbohydrates serve as bulking agents, fillers, and stabilizers in dosage forms such as tablets, capsules, and suspensions. They contribute to the physical properties of the formulation, ensuring uniformity, flowability, and compressibility. Moreover, carbohydrates are instrumental in controlling drug release kinetics, enabling sustained, controlled, or targeted drug delivery. By modulating the rate and extent of drug release, carbohydrates influence the pharmacokinetics and pharmacodynamics of drugs, optimizing therapeutic efficacy while minimizing adverse effects. In addition to their role in conventional dosage forms, carbohydrates are integral components of novel drug delivery systems. These systems, such as liposomes, microspheres, and nanoparticles, offer advantages such as targeted drug delivery, sustained release, and enhanced bioavailability. Carbohydrate-based matrices provide structural integrity and biocompatibility to these delivery systems, facilitating their application in diverse therapeutic areas. Furthermore, carbohydrates play a crucial role in parenteral formulations by serving as tonicity-adjusting agents to maintain isotonicity and osmolarity. This ensures patient safety and minimizes tissue irritation upon injection, making carbohydrates indispensable in injectable pharmaceutical products. Overall, the pharmaceutical importance of carbohydrates extends beyond their nutritional value to encompass critical functions in drug formulation, delivery, and efficacy. Their versatility, biocompatibility, and ability to modulate drug release kinetics make carbohydrates indispensable components in pharmaceuticals. As the pharmaceutical industry continues to evolve, further exploration of carbohydrate-based formulations and delivery systems holds promise for advancing drug development and improving patient outcomes.
If a standard injectable form of a drug is given every 12 hours is the sustained release form more likely to be given every 6 hours or 96 hours?
More likely would be every 96 hours - the sustained release form is the formulation that keeps blood levels of the drug elevated for longer periods of time than the standard formulation.
What is matrix tablet?
Matrix tablet is a specific formulation intended for slow/controlled/sustained release of drug at a desired location in gastro-intestinal tract.
Formulation of sustained release rectal suppository?
The formulation of sustained-release rectal suppositories involves selecting appropriate excipients that facilitate prolonged drug release while ensuring stability and bioavailability. Commonly used bases include hydrophilic polymers (e.g., polyethylene glycol) or lipid-based carriers (e.g., cocoa butter) that can control the release rate. Active pharmaceutical ingredients are usually combined with these bases, and additives like stabilizers or surfactants may be included to enhance solubility and absorption. The final formulation is then shaped into suppository molds and evaluated for consistency, release profile, and efficacy.
Is Sustained and enteric release the same?
Sustained release and enteric release are not the same. Sustained release formulations are designed to release a drug slowly over time, maintaining therapeutic levels in the bloodstream for an extended period. In contrast, enteric release formulations are designed to protect the drug from stomach acid and ensure it is released in the intestines. While both aim to enhance drug efficacy and patient compliance, they serve different purposes in drug delivery.
What are the factors influencing oral sustained- release dosage form design?
Factors influencing oral sustained-release dosage form design include drug properties (such as solubility, stability, and half-life), desired release profile, site of absorption in the gastrointestinal tract, manufacturing feasibility, patient compliance, and regulatory requirements. Additionally, considerations such as cost-effectiveness, formulation complexity, and technology advancement may also impact the design of sustained-release dosage forms.
What is eudragit?
Eudragit is a brand name for a type of polymer used in pharmaceutical formulations. It is often used as a coating for tablets to control drug release and improve stability. Eudragit polymers come in various types with different properties to suit the specific needs of a formulation.
How are mixtures important in food and drug formulation?
a mixture is important in food and drug formulation with food chain
What are polymers as capsules?
When a negatively charged polymer and a positive polymer get close enough, they will arrange themselves around each other.The dye to be released is trapped inside the polymersThe polymer layers form a barrier which prevents the drug from being dissolved before it reaches the target organThe release of drug can be controlled by the charge and number of polymer chains in the capsule
What is the mechanism in a pill to dispense an active substance or drug to the body over a sustained period?
time release
What is higuchi model?
The Higuchi model is a mathematical model used in pharmacokinetics to describe drug release from a controlled-release formulation. It is based on Fick's second law of diffusion and describes drug release as a function of the square root of time. The model is commonly used to analyze drug release kinetics from matrix systems.
Definition of novel drug delivery system?
It is advance drug delivery system which improve drug potency, control drug release to give a sustained therapeutic effect, provide greater safety, finally it is to target a drug specifically to a desired tissue
How you can calculate the maintenance dose in the formulation of controlled release tablets?
Dt = Dose (1 + 0.693 × t/t1/2) Where, Dt = Total dose, Dose = Immediate release dose, t = Total time period for which sustained release is required, t1/2 = Half-life of drug.
