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For nucleotide excision repair, the enzymes that are involved are excinucleases.
For base excision repair, the enzymes involved are DNA glycoslyases

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Helicase is involved in a reaction called DNA unwinding, which is a type of enzyme-catalyzed reaction that separates the two strands of a DNA double helix. Helicase acts by breaking the hydrogen bonds between the base pairs of DNA to allow for replication, transcription, and repair processes.


What is Nucleotide excision repair mechanism?

The most common type of DNA damage caused by the UV light is the thymine-thymine dimers and can be repaired by this nucleotide excision repair mechanism.Hence nucleotide excision repair is considered as the most important DNA repair pathway that fixes the majority of bulky lesions in DNA. These lesions include UV induced photoproducts, and bulky adducts (the DNA regions which contain chemically modified bases) such as those derived from cisplatin and 4-nitroquinoline oxide.Nucleotide excision repair pathways differ in different parts of the mammalian genome: separate pathways operate for the repair of active or essential genomic regions versus regions that are noncoding. NER Nucleotide excision repair (NER) is the most flexible of the DNA repair pathways considering the diversity of DNA lesions it acts upon.The most significant of these lesions are pyrimidine dimers (cyclobutane pyrimidine dimers and 6-4 photoproducts) caused by the UV component of sunlight.A portion of the double helix is unwound by the enzyme called as helicase.A molecule of a DNA polymerase binds to one of the double strand of the DNA and begins moving along it in the 3' to 5' direction.This strand is being used as a template for assembling a leading strand of nucleotides and reforming a double helix. In eukaryotes, this molecule is called DNA polymerase delta (δ).DNA synthesis can only occur from 5' to 3', a molecule of a second type of DNA polymerase called as epsilon (ε) in eukaryotes binds to the other template strand as the double helix opens.This molecule must synthesize discontinuous segments of polynucleotides called as Okazaki fragments.Another enzyme called as DNA ligase I then stitches these together into the lagging strand.Eva- examville tutor


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