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Aloe vera has a long association with herbal medicine, although it is not known when its medical applications were first discovered. Early records of A. vera use appear in the Ebers Papyrus from 16th century BCE, in both Dioscorides' De Materia Medica and Pliny the Elder's Natural History written in the mid-first century CE along with the Juliana Anicia Codexproduced in 512 CE. Contrary to the widespread belief that A. vera is non-toxic, excess ingestion of A. vera has been associated with a range of symptoms and conditions including diarrhea, hepatitis, kidney dysfunction, electrolyte imbalance and reduced CNS activity. However, the species is used widely in the traditional herbal medicine of China, Japan and India.

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16y ago

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