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Biotransformation is important because it involves the conversion of substances, such as drugs or toxins, into more readily excretable forms. This process helps to detoxify harmful compounds and enhance the elimination of waste products from the body. Additionally, biotransformation can also increase the activity of some drugs, making them more effective.
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What is the major organ involved in biotransformation of drugs?
The liver is the major organ involved in the biotransformation of drugs. It contains enzymes that help metabolize drugs into forms that can be easily excreted from the body.
Chemical transformation or change the interaction of chemical entities?
Biotransformation is a type of chemical change that a living organism makes on a chemical compound. If this change turns into an inorganic compound such as H2O, NH4 or CO2, it is called mineralization. Biotransformation means the change of chemicals such as nutrients, amino acids, toxins and drugs in the body. In this transformation, it is necessary to change non-polar compounds to polar compounds that are not absorbed in the open renal tubules and are excreted.
What impact of CYP450 have on the body?
Cytochrome P450 (CYP450) enzymes play a crucial role in the metabolism of various substances in the body, including drugs, toxins, and endogenous compounds. They facilitate the biotransformation of these substances, making them more water-soluble for easier excretion. Variations in CYP450 activity can influence drug efficacy and toxicity, leading to differences in individual responses to medications. Additionally, these enzymes are involved in the synthesis of important biological molecules, such as steroids and fatty acids, impacting overall metabolic processes.
What is the difference between first pass and phase one of drug metabolism?
First pass metabolism refers to the metabolism of a drug that occurs in the liver after it is absorbed from the gastrointestinal tract, before it enters systemic circulation. Phase 1 metabolism is the initial biotransformation of a drug, primarily carried out by enzymes such as cytochrome P450, to make the drug more polar and easier to eliminate from the body.
The plasmid pARA-R has been genetically modified for what purpose?
The plasmid pARA-R has been genetically modified to contain aarF gene from the Candida boidinii yeast which codes for aryl-alcohol dehydrogenase, an enzyme that can convert aromatic alcohols to their corresponding aldehydes. This modification allows for the efficient conversion of aromatic alcohols to aldehydes in biotransformation processes.
What is the important of the biotransformation xenobiotics?
Biotransformation of xenobiotics is important because it helps in converting these foreign compounds into more water-soluble forms that can be easily excreted from the body. This process makes the xenobiotics less toxic and facilitates their elimination through urine or bile. It also helps in rendering these compounds inactive or less harmful to the body.
What is a biotransformation?
A biotransformation is a combination of the changes which occur to a substance by the actions of enzymes within an organism.
What has the author Siegfried Pfeifer written?
Siegfried Pfeifer has written: 'Biotransformation von Arzneimitteln' -- subject(s): Biotransformation drugs, Drugs, Metabolism
Is pharmacotherapeutics part of biotransformation?
Pharmacotherapeutics and biotransformation are related but distinct concepts. Pharmacotherapeutics refers to the study of how drugs interact with the body to produce therapeutic effects, while biotransformation specifically pertains to the chemical modifications made by the body to drugs and other substances, primarily in the liver. Biotransformation is a crucial aspect of pharmacokinetics, influencing drug efficacy and safety, but it is only one component of the broader field of pharmacotherapeutics.
What is the major organ involved in biotransformation of drugs?
The liver is the major organ involved in the biotransformation of drugs. It contains enzymes that help metabolize drugs into forms that can be easily excreted from the body.
What is plant biotransformation?
Plant Biotransformation is the use of plants as a catalyst for specific conversion of complex substrates. One use of this biotransformation is to clone and over express genes in key enzymes. These can be used in chemical creations or even improving soil quality.
The pharmacological effects of administering insulin to a hyperglycemic patient is an example of increased?
biotransformation
What has the author Md Akhter Hossain written?
Md. Akhter Hossain has written: 'Modeling the anaerobic biotransformation and transport of chlorinated hydrocarbons in groundwater' -- subject(s): Hydrocarbons, Groundwater, Microbiological synthesis, Biotransformation (Metabolism), Biodegradation, Soil pollution, Pollution
What has the author Mirjana Zabic written?
Mirjana Zabic has written: 'Investigation of regio- and sterochemistries of microbial biotransformation'
What has the author Matthew Bycroft written?
Matthew Bycroft has written: 'Optimisation of biotransformation activity of recombinant escherichia pBUD62'
What has the author P Phumathon written?
P. Phumathon has written: 'Biotransformation of toluene to toluene cis-glycol by recombinant escherichia coli strains'
What is the difference between drug elimination and excretion?
Elimination is carried out by 2 process - biotransformation and - excretionExcretion means complete removal of drug and its metabolites from internal nvironment to external enviroment.
