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Short answer: Distillation heats a liquid mixture and then cools the vapor that boils off to recover the more volatile portion of the original mixture. If you have a leaky apparatus you can lose a lot of this volatile portion because it will leak into the atmosphere before it has a chance to condense into your receiving vessel. This wastes energy and can create a fire or explosion hazard if you are distilling flammable liquids. It will create health or environmental problems if you are working with toxic materials or materials that are harmful to the environment.

Long answer: Distillation works by either heating a liquid to produce vapor or reducing the pressure over a liquid to make it boil into a vapor at a lower temperatures. The vapor must be condensed by cooling to recover the "distallate" product you are after. With heated distillation you will lose much of the vapor through before you can condense it if you have a leaky apparatus. This is especially true if the distillation occurs at high pressures. For vacuum distillation you may not be able to create enough vacuum to cause the liquid mixture to boil if there are any large leaks or you will waste a lot of power creating the needed vacuum pressure in a leaky distillation column.

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