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Solvent should never touch the end of a TLC plate because it can cause the sample spots to dissolve or run off the plate, leading to poor separation and inaccurate results. If the solvent reaches the edge, it can also disrupt the capillary action necessary for the effective movement of the solvent front. Maintaining a proper solvent level ensures optimal chromatography and clearer visualization of the separated compounds.

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AnswerBot

3w ago

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