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methylation protects the DNA. Beside using dT instead of dU, most organisms also use various enzymes to modify DNA after it has been synthesized. Two such enzymes, dam and dcmmethylate adenines and cytosines, respectively, along the entire DNA strand. This methylation makes the DNA unrecognizable to many Nucleases (enzymes which break down DNA and RNA), so that it cannot be easily attacked by invaders, like viruses or certain bacteria. Obviously, methylating the nucleotides before they are incorporated ensures that the entire strand of DNA is protected. Thymine also protects the DNA in another way. If you look at the components of nucleic acids, phosphates, sugars, and bases, you see that they are all very hydrophilic (water soluble). Obviously, adding a hydrophobic (water insoluble) methyl group to part of the DNA is going to change the characteristics of the molecule. The major effect is that the methyl group will be repelled by the rest of the DNA, moving it to a fixed position in the major groove of the helix. This solves an important problem with uracil - though it prefers adenine, uracil can base-pair with almost any other base, including itself, depending on how it situates itself in the helix. By tacking it down to a single conformation, the methyl group restricts uracil (thymine) to pairing only with adenine. This greatly improves the efficiency of DNA replication, by reducing the rate of mismatches, and thus mutations. To sum up: the replacement of thymine for uracil in DNA protects the DNA from attack and maintains the fidelity of DNA replication. Sunil Nagpal B.tech(h)Biotechnology 2nd year LPU-Jalandhar(punjab)(India)

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Related Questions

Is uracil present in DNA or RNA?

Uracil is present in RNA, but not in DNA.


What is in RNA but not in DNA?

Uracil


What base is not present in the nucleotides of RNA?

RNA has the base uracil rather than thymine that is present in DNA, so the answer to you question is.. thymine.


What nucleotide is present in rna and not in DNA?

uracil


What doesn't have uracil in DNA?

Uracil is not naturally present in DNA. Instead, it is found in RNA, where it replaces the thymine base found in DNA. Thymine is the corresponding base in DNA and is not found in RNA.


Which nitrogen base is not used during replication?

Uracil. Uracil is not present in DNA, but it is present in RNA. DNA's "equivalent" base is thymine, meaning when DNA is transcribed into RNA, the places where thymine would go instead has uracil.


What is a pyrimidine base found in RNA but not in DNA?

Thymine


Pyrimidine base found in RNA but not DNA?

Uracil is the pyrimidine base found in RNA that is not present in DNA. Uracil pairs with adenine in RNA during transcription and translation processes.


What molecule is found in DNA but not in RNA?

The SUGAR found in DNA but not RNA is Codo.


What nucleotide base is part of transcription that is not part of the DNA?

During transcription, uracil is the nucleotide base that is incorporated into RNA but is not found in DNA. In RNA, uracil replaces thymine, which is present in DNA. This substitution occurs as RNA polymerase synthesizes RNA from the DNA template, pairing uracil with adenine.


What is the nitrogen base in RNA that DNA doesn't have?

4 NITROGEN BASIS OF DNA:ADENINE GUANINECYTOSINETHYMINEIN RNA, Thymine changes to Uracil.


Which base is a component of RNA only uracil adenine cytosine guanine or thymine?

Uracil is the base that is a component of RNA only. Thymine is found in DNA, while adenine, cytosine, and guanine are present in both RNA and DNA.

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