Very simply, it's a trail that runs through the Appalachian Mountains.
Appalachian Mountains.
Names for these can include the Rocky Mountains the Mississippi River and the Great Plains.
The region is Appalachian Plateau.
The Appalachian mountains, the Hudson River, the Potomac River and the Great Lakes to name a few
The Great Plains
Mississippi river Mississippi river
The Appalachian Mountains
Mississippi is the name of a river and a state.
The Great Plains
Appalachian Mountains (oldest in US)
Apalachee