Infants are at risk for drug toxicity due to their immature liver and kidneys, which are not fully developed and can impair drug metabolism and excretion. Additionally, their body composition differs from adults, with a higher percentage of water and lower fat content, affecting drug distribution and concentration. Infants also have different enzyme activity levels, which can alter drug efficacy and safety. Lastly, dosing is often based on weight, and errors in calculation or administration can lead to overdosing or underdosing.
The toxicity profile of this drug when administered systemically includes granulocytopenia, anemia and thrombocytopenia. The drug is in pregnancy category C
infants, young children
Some disadvantages of prodrugs include potential variability in conversion to the active drug due to individual differences in metabolism, the risk of inactive metabolites causing toxicity, and the need for additional steps in drug processing which can complicate drug development and regulation.
It's called Toxicity. (This is the actual definition)
Infants born to drug addicted mothers tend to be drug addicted themselves. Mothers should not become pregnant when they are actively using drugs.
Vitamin A supplements should not be taken in conjunction with any retinoid medications, including isotretinoin (Accutane), a drug used to treat acne. There is a higher risk of toxicity.
In rare cases, initiation of ribavirin therapy has led to deterioration of respiratory function in infants.
Not to be taken with monoamine oxidase inhibitor or antidepressants. Interferes with antidiabetic drugs, increase the activity of diuretics and increases risk of toxicity to aspirin or NSAIDs. And more . . .
yes.
Infants
Infants are most at risk for Sudden Infant Death Syndrome (SIDS) between the ages of 1 and 4 months.
Vitamins A and D