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I'll bet you're thinking it was the Bubonic Plague, but you'd be wrong. The plague epidemic struck Europe in the early fourteenth century and one person in three died. The disease was still around in Shakespeare's day, but it had "hit Europe" two hundred and fifty years before. The deadly disease that his Europe in Shakespeare's time was syphilis, which was brought from the New World by Columbus's sailors and spread through Europe like wildfire in the sixteenth century. Shakespeare's plays are full of references to it.

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