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The line is "Stand you directly in Antonius' way when he doth run his course" and is said by Caesar to his wife Calpurnia. Antony is one of the men running in the footrace which is traditional on the Lupercal celebrations. The word "course" has the same meaning as in the expressions "race course" or "Golf course"; it is the path which the contestants have to follow. To run his course is to run the race along the prescribed path.

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Q: What is the meaning of the word run his course said by Caesar in Act 1 Scene 2 line 4?
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