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The Black Death was an epidemic of Bubonic Plague which swept through Europe in the 1300s and killed one-third of the population. It was called the Black Death because it attacked the lymphatic system and caused blue-black lumps called buboes to form in the lymphatic nodes.

By Shakespeare's day, two hundred years later, it had died out.

The plague virus had, however mutated and a new disease was a problem, called Pneumonic Plague, because it attacked the lungs rather than the lymphatic system. This kind of plague made frequent outbreaks throughout England during Shakespeare's life. Shakespeare's sister Anne died of it. The theatre business was severely curtailed on several occasions when the theatres were all closed as a health measure during outbreaks.

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