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She kills herself. After convincing Macbeth to kill so many people to get power, her guilt kicks in. This guilt is manifest when she walks in her sleep, talking of washing her hands of the blood, i.e. guilt. It eventually completely consumes her, and she commits suicide.

In Act 5, Scene 1, a Doctor and Gentlewoman observe Lady Macbeth sleepwalking. After observing, the doctor advises the Gentlewoman to "Remove from her the means of all annoyance" (V i 78). He is telling her to keep away from Lady Macbeth anything she could use to kill herself.

In Act 5, Scene 5, Macbeth hears a cry within of women,and it can be assumed that this is either Lady Macbeth or her attendants who have discovered her dead body. Seyton, a nobleman loyal to Macbeth, comes to him and says "The Queen, my lord, is dead." (V v 18).

In the final speech of the play, in Act 5, Scene 8, Malcolm refers to Macbeth's "fiend-like Queen, who, as 'tis thought, by self and violent hands took off her life." (V iix 81-83). This means that it is believed by most people that Lady Macbeth commited suicide.

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