Quite a lot of things, actually: the English Civil War, the French Revolution, the discovery of smallpox vaccine, the settlement of the American West, the discovery of the internal combustion engine, the fall of the Manchus in China, the invention of the internet. Yes, a lot of things have happened since 1616.
Or are you asking what events were caused by Shakespeare's death? Not much, really: his family was sad and most of his property went to his daughter Susanna Hall, and some of his theatrical friends started to think it might be a nice tribute to gather up all the Shakespeare scripts they had lying about and publish them in one volume.
William Shakespere left some money to his daughters Susanna and Judith. He left his wife Anne, his "second-best bed with the furniture".
https://en.wikipedia.org/wiki/Anne_Hathaway_(wife_of_Shakespeare)
Most of his property went to his eldest daughter, Susanna, and her husband Dr. John Hall. A provision was made for the second daughter Judith, but it was tied up to prevent her spendthrift husband getting at it. There is hardly any mention of Shakespeare's wife, Anne. It is assumed that he was satisfied with her getting the share of the estate (one-third) which was the minimum a widow could get by the Dower Law.
Shakespeare was 36 years old and an established actor and playwright when his father died. He didn'r need looking after.
Joan survived William and inherited their parents' house from him.
Shakespeare's parents had two daughters before William, but they both died as babies long before William's birth.
John and Mary Shakespeare had two children (both girls) who died as infants before William was born in 1564. All of his siblings that grew to adulthood were younger than him.
William Shakespeare Burton died in 1916.
William Shakespeare Hall died on 1895-02-11.
Joan survived William and inherited their parents' house from him.
William Shakespeare's parents were John Shakespeare, who was an alderman, glover and a leather worker, and Mary Arden, who was the daughter of an affluent landowning farmer. John Shakespeare was born circa 1531 and died in 1601. Mary Arden was born circa 1537 and died in 1608.
Shakespeare's parents had two daughters before William, but they both died as babies long before William's birth.
William Shakespeare died in 1616.
William Shakespeare's parents were John and Mary. His mother Mary was Mary Arden before she married his father. They were married sometime between 1556 and 1558. They died in 1601 and 1608.
John and Mary Shakespeare had two children (both girls) who died as infants before William was born in 1564. All of his siblings that grew to adulthood were younger than him.
William Shakespeare died on 23rd April 1616.
william shakespeare died at the age of 52.
William Shakespeare - cricketer - died in 1976.
William Shakespeare Hays died in 1907.
William Shakespeare Burton died in 1916.
Shakespeare's son Hamnet died in 1596 when he was only eleven. Shakespeare was also predeceased by his parents and all of his brothers. He was survived by his wife, his two daughters, and his sister Joan.