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E = mc2 is a fundamental equation which applies everywhere in the universe as far as we know. In everyday life the energy transfers are not large enough to notice changes of mass, which explains why Newton and others never considered such factors and Einstein was the first to explain it mathematically, but even so many scientists were sceptical. The power coming from a nuclear reactor is derived from mass changes in the nucleus releasing this energy, so that is the nearest I can think of to everyday life.

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Q: Does Emc2 work only in the Sun or in other examples of fission and fusion Are there any instances of its operation in everyday life?
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