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A tight junction is a specialized connection between adjacent epithelial cells that forms a barrier to prevent the passage of molecules and ions through the space between cells. It consists of strands of proteins, such as claudins and occludins, that seal the gaps and maintain cell polarity by separating apical and basolateral surfaces. Tight junctions are crucial for maintaining the integrity of tissues and regulating the movement of substances across epithelial layers. They play a significant role in various physiological processes, including fluid balance and nutrient absorption.

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