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Take the Downtown 2 or 3 trains (of the 1-2-3, the red line) from 34th Street-Penn Station to Chambers Street (at West Broadway).

You could also take the 1, but you don't want to, because the 1 is a local train and there are many stops from Penn Station to Chambers Street. It's only 2 stops on the 2 and 3 trains.

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