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Tight junctions are crucial for maintaining the integrity of epithelial and endothelial barriers in tissues, preventing the free passage of substances between cells. They regulate the movement of ions and molecules, ensuring selective permeability that is vital for physiological functions. This barrier function protects underlying tissues from pathogens and toxins, while also playing a key role in maintaining homeostasis. Additionally, tight junctions are important for cell signaling and maintaining cell polarity.

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1w ago

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