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No. Alexander the great lived over 150 years after Ezra died.

Answer:As far as I know, the synod called the Men of the Great Assembly (a special Sanhedrin of sages including Ezra) had already completed sealing the canon of the Tanakh (Hebrew Bible) before Alexander came to the land of Judea.

In general, Alexander's power had a mixed effect in Judea. On the one hand, he showed honor to the Sages (Talmud, Tamid 32a) and the Cohen Gadol (Talmud, Yoma 69a), and he rebuffed the annoyances of our detractors (ibid; and Sanhedrin 91a). On the other hand, he ushered in the Greek language and culture, which created a melting-pot of Hellenism and assimilation in the following generations.

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