It is a social construct. It is not natural to have a feminine appearance and a penis and to want to model in porn. However, the term shemale is offensive and should be avoided.
Now if you mean actual transsexualism, a person might be born trapped in the wrong body, and then they take hormones and get surgery to fix that.
Natural is to nature as artificial is to artifice.
The definitions is : Natural- A natural plant Artificial- An artificial one
Antonyms for "artificial" are genuine, real, and natural.
artificial
natural
artificial can't be found in natural environment and are maken in labs
Natural silk is a proteinic fiber (sericin and fibroin).
Artificial. Man made.
artificial
Artificial is not natural, is man made.
Curium is an artificial element.
Natural