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Three major hazards for nuclear waste storage sites include groundwater contamination, seismic activity, and human intrusion. Groundwater contamination can occur if waste leaks from storage containers, posing risks to drinking water supplies. Seismic activity can compromise the structural integrity of storage facilities, leading to potential releases of radioactive materials. Human intrusion, such as mining or construction, could inadvertently disturb waste repositories, increasing the risk of exposure to hazardous materials.

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